Set in the Western United States during the Ulysses S. Grant administration, The Primetime Emmy Award winning series follows Secret Service agents James West and Artemus Gordon. James is a daring man of action, while Artemus is a master of disguise and gadgets. They operate from a private train headquarters, battling a variety of mad scientists and criminal masterminds, with their main adversary being the Evil Genius Dr. Miguelito Loveless.