ESCAPE AT DANNEMORA is based on the stranger-than-fiction prison break in upstate New York in the summer of 2015 which spawned a statewide manhunt for two convicted murderers, aided in their escape by a married female prison employee who carried on months-long affairs with both men. Del Toro plays convicted murderer Richard Matt, an artistic yet intimidating force within the prison, who masterminds the escape. Arquette plays Tilly Mitchell, a working class wife and mother who supervises the prison tailor shop and becomes sexually involved with both men, ultimately agreeing to hide hacksaw blades in frozen hamburger meat to help them get out. Dano plays David Sweat, a convicted cop-killer who may have genuine feelings for Tilly and becomes a reluctant partner in Richard Matt's plot.