The 12th Victim sheds new light on the infamous 1958 Charles Starkweather and Caril Ann Fugate murder case, in which the teenage couple was charged and convicted of brutally killing 11 victims at random. Told through a stylistic blend of archival and recreated footage and countless film and television series inspired by the killings, The 12th Victim reexamines Fugate's guilty verdict, who was 14 years old at the time of the killings, through a modern lens, questioning the media and judicial system's treatment of her despite her self-proclaimed innocence.